$\begingroup$ it's more a please check that I have taken care of the random effects, autocorrelation, and a variance that increases with the mean properly. $\endgroup$ – M.T.West Sep 22, 2015 at 12:15Aug 14, 2021 · the mixed-effect model with a first-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ). An extension of the mixed-effects growth model that considers between-person differences in the within-subject variance and the autocorrelation. Stat Med. 2022 Feb 10;41 (3):471-482. doi: 10.1002/sim.9280.Jul 9, 2023 · For a linear mixed-effects model (LMM), as fit by lmer, this integral can be evaluated exactly. For a GLMM the integral must be approximated. For a GLMM the integral must be approximated. The most reliable approximation for GLMMs is adaptive Gauss-Hermite quadrature, at present implemented only for models with a single scalar random effect. Sep 16, 2018 · Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ... This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement. This is what we refer to as “random factors” and so we arrive at mixed effects models. Ta-daa! 6. Mixed effects models. A mixed model is a good choice here: it will allow us to use all the data we have (higher sample size) and account for the correlations between data coming from the sites and mountain ranges.At this point, it is important to highlight how spatial data is internally stored in a SpatialGridDataFrame and the latent effects described in Table 7.1. For some models, INLA considers data sorted by column, i.e., a vector with the first column of the grid from top to bottom, followed by the second column and so on.Feb 23, 2022 · It is evident that the classical bootstrap methods developed for simple linear models should be modified to take into account the characteristics of mixed-effects models (Das and Krishen 1999). In ... Apr 11, 2023 · Inspecting and modeling residual autocorrelation with gaps in linear mixed effects models. Here I generate a dataset where measurements of response variable y and covariates x1 and x2 are collected on 30 individuals through time. Each individual is denoted by a unique ID . Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2).the mixed-effect model with a first-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ).10.8k 7 39 67. 1. All LMMs correspond to a multivariate normal model (while the converse is not true) with a structured variance covariance matrix, so "all" you have to do is to work out the marginal variance covariance matrix for the nested random-effect model and fit that - whether gls is then able to parameterize that model is then the next ...This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement. Linear mixed-effect model without repeated measurements. The OLS model indicated that additional modeling components are necessary to account for individual-level clustering and residual autocorrelation. Linear mixed-effect models allow for non-independence and clustering by describing both between and within individual differences.A comparison to mixed models. We noted previously that there were ties between generalized additive and mixed models. Aside from the identical matrix representation noted in the technical section, one of the key ideas is that the penalty parameter for the smooth coefficients reflects the ratio of the residual variance to the variance components for the random effects (see Fahrmeier et al ...of freedom obtained by the same method used in the most recently fit mixed model. If option dfmethod() is not specified in the previous mixed command, option small is not allowed. For certain methods, the degrees of freedom for some linear combinations may not be available. See Small-sample inference for fixed effects in[ME] mixed for more ... Dec 12, 2022 · It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ... Jul 1, 2021 · Mixed Effects Models - Autocorrelation. Jul. 1, 2021 • 0 likes • 171 views. Download Now. Download to read offline. Education. Lecture 19 from my mixed-effects modeling course: Autocorrelation in longitudinal and time-series data. Scott Fraundorf Follow. Growth curve models (possibly Latent GCM) Mixed effects models. 이 모두는 mixed model 의 다른 종류를 말한다. 어떤 용어들은 역사가 깊고, 어떤 것들은 특수 분야에서 자주 사용되고, 어떤 것들은 특정 데이터 구조를 뜻하고, 어떤 것들은 특수한 케이스들이다. Mixed effects 혹은 mixed ...the mixed-effect model with a first-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ).The first model was a longitudinal mixed-effect model with a first-order autocorrelation structure, and the second model was the E-MELS. Both were implemented as described above. The third model was a longitudinal mixed-effect model with a Lasso penalty. A random effects model that contains only random intercepts, which is the most common use of mixed effect modeling in randomized trials, assumes that the responses within subject are exchangeable. This can be seen from the statement of the linear mixed effects model with random intercepts.Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5]. Apr 11, 2023 · Inspecting and modeling residual autocorrelation with gaps in linear mixed effects models. Here I generate a dataset where measurements of response variable y and covariates x1 and x2 are collected on 30 individuals through time. Each individual is denoted by a unique ID . PROC MIXED in the SAS System provides a very flexible modeling environment for handling a variety of repeated measures problems. Random effects can be used to build hierarchical models correlating measurements made on the same level of a random factor, including subject-specific regression models, while a variety of covariance andGLMMs. In principle, we simply define some kind of correlation structure on the random-effects variance-covariance matrix of the latent variables; there is not a particularly strong distinction between a correlation structure on the observation-level random effects and one on some other grouping structure (e.g., if there were a random effect of year (with multiple measurements within each year ...What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals. Apr 11, 2023 · Inspecting and modeling residual autocorrelation with gaps in linear mixed effects models. Here I generate a dataset where measurements of response variable y and covariates x1 and x2 are collected on 30 individuals through time. Each individual is denoted by a unique ID . The following simulates and fits a model where the linear predictor in the logistic regression follows a zero-mean AR(1) process, see the glmmTMB package vignette for more details.Mixed Models (GLMM), and as our random effects logistic regression model is a special case of that model it fits our needs. An overview about the macro and the theory behind is given in Chapter 11 of Littell et al., 1996. Briefly, the estimating algorithm uses the principle of quasi-likelihood and an approximation to the likelihood function of ... Apr 15, 2016 · 7. I want to specify different random effects in a model using nlme::lme (data at the bottom). The random effects are: 1) intercept and position varies over subject; 2) intercept varies over comparison. This is straightforward using lme4::lmer: lmer (rating ~ 1 + position + (1 + position | subject) + (1 | comparison), data=d) > ... Linear Mixed Effects Models. Linear Mixed Effects models are used for regression analyses involving dependent data. Such data arise when working with longitudinal and other study designs in which multiple observations are made on each subject. Some specific linear mixed effects models are. Random intercepts models, where all responses in a ...It is a linear mixed model, with log-transformed OM regressed on marsh site (categorical), marsh type (categorical), soil category (categorical), depth (numerical, based on ordinal depth ranges), and the interaction between depth and marsh type; marsh site effects are modeled as random, on which the ICAR spatial autocorrelation structure is ...Growth curve models (possibly Latent GCM) Mixed effects models. 이 모두는 mixed model 의 다른 종류를 말한다. 어떤 용어들은 역사가 깊고, 어떤 것들은 특수 분야에서 자주 사용되고, 어떤 것들은 특정 데이터 구조를 뜻하고, 어떤 것들은 특수한 케이스들이다. Mixed effects 혹은 mixed ... 7. I want to specify different random effects in a model using nlme::lme (data at the bottom). The random effects are: 1) intercept and position varies over subject; 2) intercept varies over comparison. This is straightforward using lme4::lmer: lmer (rating ~ 1 + position + (1 + position | subject) + (1 | comparison), data=d) > ...Linear mixed model fit by maximum likelihood [’lmerMod’] AIC BIC logLik deviance df.resid 22.5 25.5 -8.3 16.5 17 Random effects: Groups Name Variance Std.Dev. operator (Intercept) 0.04575 0.2139 *** Operator var Residual 0.10625 0.3260 estimate is smaller. Number of obs: 20, groups: operator, 4 Results in smaller SE for the overall Fixed ... This is what we refer to as “random factors” and so we arrive at mixed effects models. Ta-daa! 6. Mixed effects models. A mixed model is a good choice here: it will allow us to use all the data we have (higher sample size) and account for the correlations between data coming from the sites and mountain ranges.Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). An individual-tree diameter growth model was developed for Cunninghamia lanceolata in Fujian province, southeast China. Data were obtained from 72 plantation-grown China-fir trees in 24 single-species plots. Ordinary non-linear least squares regression was used to choose the best base model from among 5 theoretical growth equations; selection criteria were the smallest absolute mean residual ...Because I have 4 observations for each Site but I am not interested in this effect, I wanted to go for a Linear Mixed Model with Site as random effect. However, climatic variables are often highly spatially autocorrelated so I also wanted to add a spatial autocorrelation structure using the coordinates of the sites.Dec 24, 2014 · Is it accurate to say that we used a linear mixed model to account for missing data (i.e. non-response; technology issues) and participant-level effects (i.e. how frequently each participant used ... There is spatial autocorrelation in the data which has been identified using a variogram and Moran's I. The problem is I tried to run a lme model, with a random effect of the State that district is within: mod.cor<-lme(FLkm ~ Monsoon.Precip + Monsoon.Temp,correlation=corGaus(form=~x+y,nugget=TRUE), data=NE1, random = ~1|State)Your second model is a random-slopes model; it allows for random variation in the individual-level slopes (and in the intercept, and a correlation between slopes and intercepts) m2 <- update(m1, random = ~ minutes|ID) I'd suggest the random-slopes model is more appropriate (see e.g. Schielzeth and Forstmeier 2009). Some other considerations:c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of β (1) this assumes the temporal pattern is the same across subjects; (2) because gamm() uses lme rather than lmer under the hood you have to specify the random effect as a separate argument. (You could also use the gamm4 package, which uses lmer under the hood.) You might want to allow for temporal autocorrelation. For example,Linear mixed models allow for modeling fixed, random and repeated effects in analysis of variance models. “Factor effects are either fixed or random depending on how levels of factors that appear in the study are selected. An effect is called fixed if the levels in the study represent all possible levels of theMixed Models (GLMM), and as our random effects logistic regression model is a special case of that model it fits our needs. An overview about the macro and the theory behind is given in Chapter 11 of Littell et al., 1996. Briefly, the estimating algorithm uses the principle of quasi-likelihood and an approximation to the likelihood function of ... However, in the nlme R code, both methods inhabit the ‘correlation = CorStruc’ code which can only be used once in a model. Therefore, it appears that either only spatial autocorrelation or only temporal autocorrelation can be addressed, but not both (see example code below).Phi = 0.914; > - we have a significant treatment effect; > - and when I calculate effective degrees of freedom (after Zuur et al "Mixed Effects Models and Extensions in Ecology with R" pg.113) I get 13.1; hence we aren't getting much extra information from each time-series given the level of autocorrelation, but at least we have dealt with data ...Spatial and temporal autocorrelation can be problematic because they violate the assumption that the residuals in regression are independent, which causes estimated standard errors of parameters to be biased and causes parametric statistics no longer follow their expected distributions (i.e. p-values are too low).Zuur et al. in \"Mixed Effects Models and Extensions in Ecology with R\" makes the point that fitting any temporal autocorrelation structure is usually far more important than getting the perfect structure. Start with AR1 and try more complicated structures if that seems insufficient.Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...How is it possible that the model fits perfectly the data while the fixed effect is far from overfitting ? Is it normal that including the temporal autocorrelation process gives such R² and almost a perfect fit ? (largely due to the random part, fixed part often explains a small part of the variance in my data). Is the model still interpretable ?Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization. Jul 1, 2021 · Mixed Effects Models - Autocorrelation. Jul. 1, 2021 • 0 likes • 171 views. Download Now. Download to read offline. Education. Lecture 19 from my mixed-effects modeling course: Autocorrelation in longitudinal and time-series data. Scott Fraundorf Follow. To use such data for predicting feelings, beliefs, and behavior, recent methodological work suggested combinations of the longitudinal mixed-effect model with Lasso regression or with regressi … A Lasso and a Regression Tree Mixed-Effect Model with Random Effects for the Level, the Residual Variance, and the Autocorrelation Aug 9, 2023 · Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ... At this point, it is important to highlight how spatial data is internally stored in a SpatialGridDataFrame and the latent effects described in Table 7.1. For some models, INLA considers data sorted by column, i.e., a vector with the first column of the grid from top to bottom, followed by the second column and so on. It is evident that the classical bootstrap methods developed for simple linear models should be modified to take into account the characteristics of mixed-effects models (Das and Krishen 1999). In ...At this point, it is important to highlight how spatial data is internally stored in a SpatialGridDataFrame and the latent effects described in Table 7.1. For some models, INLA considers data sorted by column, i.e., a vector with the first column of the grid from top to bottom, followed by the second column and so on.Linear mixed model fit by maximum likelihood [’lmerMod’] AIC BIC logLik deviance df.resid 22.5 25.5 -8.3 16.5 17 Random effects: Groups Name Variance Std.Dev. operator (Intercept) 0.04575 0.2139 *** Operator var Residual 0.10625 0.3260 estimate is smaller. Number of obs: 20, groups: operator, 4 Results in smaller SE for the overall Fixed ... Therefore, even greater sampling rates will be required when autocorrelation is present to meet the levels prescribed by analyses of the power and precision when estimating individual variation using mixed effect models (e.g., Wolak et al. 2012; Dingemanse and Dochtermann 2013)Nov 1, 2019 · Therefore, even greater sampling rates will be required when autocorrelation is present to meet the levels prescribed by analyses of the power and precision when estimating individual variation using mixed effect models (e.g., Wolak et al. 2012; Dingemanse and Dochtermann 2013) We conducted a small simulation study to investigate whether an extension of the mixed-effect model that considers between-person differences in the Level 1 variance and the autocorrelation (i.e., the E-MELS) yields more precise forecasts than a standard longitudinal mixed-effect model.Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...In order to assess the effect of autocorrelation on biasing our estimates of R when not accounted for, the simulated data was fit with random intercept models, ignoring the effect of autocorrelation. We aimed to study the effect of two factors of sampling on the estimated repeatability: 1) the period of time between successive observations, and ...An individual-tree diameter growth model was developed for Cunninghamia lanceolata in Fujian province, southeast China. Data were obtained from 72 plantation-grown China-fir trees in 24 single-species plots. Ordinary non-linear least squares regression was used to choose the best base model from among 5 theoretical growth equations; selection criteria were the smallest absolute mean residual ...What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals.A comparison to mixed models. We noted previously that there were ties between generalized additive and mixed models. Aside from the identical matrix representation noted in the technical section, one of the key ideas is that the penalty parameter for the smooth coefficients reflects the ratio of the residual variance to the variance components for the random effects (see Fahrmeier et al ...3.1 The nlme package. nlme is a package for fitting and comparing linear and nonlinear mixed effects models. It let’s you specify variance-covariance structures for the residuals and is well suited for repeated measure or longitudinal designs.a combination of both models (ARMA). random effects that model independence among observations from the same site using GAMMs. That is, in addition to changing the basis as with the nottem example, we can also add complexity to the model by incorporating an autocorrelation structure or mixed effects using the gamm() function in the mgcv packageYour second model is a random-slopes model; it allows for random variation in the individual-level slopes (and in the intercept, and a correlation between slopes and intercepts) m2 <- update(m1, random = ~ minutes|ID) I'd suggest the random-slopes model is more appropriate (see e.g. Schielzeth and Forstmeier 2009). Some other considerations: Oct 11, 2022 · The code below shows how the random effects (intercepts) of mixed models without autocorrelation terms can be extracted and plotted. However, this approach does not work when modelling autocorrelation in glmmTMB. Use reproducible example data from this question: glmmTMB with autocorrelation of irregular times spaMM fits mixed-effect models and allow the inclusion of spatial effect in different forms (Matern, Interpolated Markov Random Fields, CAR / AR1) but also provide interesting other features such as non-gaussian random effects or autocorrelated random coefficient (ie group-specific spatial dependency). spaMM uses a syntax close to the one used ...What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals.My approach is to incorporate routes and year as random effects in generalized mixed effects models as shown below (using lme4 package). But, I am not sure how well autocorrelation is modeled adequately in this way. glmer (Abundance ~ Area_harvested + (1 | route) + (1 | Year), data = mydata, family = poisson) Although I specified Poisson above ...Aug 14, 2021 · the mixed-effect model with a first-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ). Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5].spaMM fits mixed-effect models and allow the inclusion of spatial effect in different forms (Matern, Interpolated Markov Random Fields, CAR / AR1) but also provide interesting other features such as non-gaussian random effects or autocorrelated random coefficient (ie group-specific spatial dependency). spaMM uses a syntax close to the one used ...Nov 10, 2018 · You should try many of them and keep the best model. In this case the spatial autocorrelation in considered as continous and could be approximated by a global function. Second, you could go with the package mgcv, and add a bivariate spline (spatial coordinates) to your model. This way, you could capture a spatial pattern and even map it. Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...An extension of the mixed-effects growth model that considers between-person differences in the within-subject variance and the autocorrelation. Stat Med. 2022 Feb 10;41 (3):471-482. doi: 10.1002/sim.9280.Jul 25, 2020 · How is it possible that the model fits perfectly the data while the fixed effect is far from overfitting ? Is it normal that including the temporal autocorrelation process gives such R² and almost a perfect fit ? (largely due to the random part, fixed part often explains a small part of the variance in my data). Is the model still interpretable ? Aug 8, 2018 · 3. MIXED EFFECTS MODELS 3.1 Overview of mixed effects models When a regression contains both random and fixed effects, it is said to be a mixed effects model, or simply, a mixed model. Fixed effects are those with which most researchers are familiar. Any covariate that is assumed to have the same effect for all responses throughout the How is it possible that the model fits perfectly the data while the fixed effect is far from overfitting ? Is it normal that including the temporal autocorrelation process gives such R² and almost a perfect fit ? (largely due to the random part, fixed part often explains a small part of the variance in my data). Is the model still interpretable ?I have temporal blocks in my data frame, so I took the effect of time dependency through a random intercept in a glmer model. Now I want to test the spatial autocorrelation in the residuals but I’m not sure if the test procedure based on the residual is the same as for the fixed-effect models since now I have time dependency.
Zuur et al. in \"Mixed Effects Models and Extensions in Ecology with R\" makes the point that fitting any temporal autocorrelation structure is usually far more important than getting the perfect structure. Start with AR1 and try more complicated structures if that seems insufficient.. Which sam
Here's a mixed model without autocorrelation included: cmod_lme <- lme(GS.NEE ~ cYear, data=mc2, method="REML", random = ~ 1 + cYear | Site) and you can explore the autocorrelation by using plot(ACF(cmod_lme)) .Mixed Models (GLMM), and as our random effects logistic regression model is a special case of that model it fits our needs. An overview about the macro and the theory behind is given in Chapter 11 of Littell et al., 1996. Briefly, the estimating algorithm uses the principle of quasi-likelihood and an approximation to the likelihood function of ... Dec 24, 2014 · Is it accurate to say that we used a linear mixed model to account for missing data (i.e. non-response; technology issues) and participant-level effects (i.e. how frequently each participant used ... Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...Eight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). The PBmodcomp function can only be used to compare models of the same type and thus could not be used to test an LME model (Model IV) versus a linear model (Model V), an autocorrelation model (Model VIII) versus a linear model (Model V), or a mixed effects autocorrelation model (Models VI-VII) versus an autocorrelation model (Model VIII).we use corCAR1, which implements a continuous-time first-order autocorrelation model (i.e. autocorrelation declines exponentially with time), because we have missing values in the data. The more standard discrete-time autocorrelation models (lme offers corAR1 for a first-order model and corARMA for a more general model) don’t work with ...a random effect for the autocorrelation. After introducing the extended mixed-effect location scale (E-MELS), ... mixed-effect models that have been, for example, combined with Lasso regression (e ...Yes. How can glmmTMB tell how far apart moments in time are if the time sequence must be provided as a factor? The assumption is that successive levels of the factor are one time step apart (the ar1 () covariance structure does not allow for unevenly spaced time steps: for that you need the ou () covariance structure, for which you need to use ...Linear Mixed Effects Models. Linear Mixed Effects models are used for regression analyses involving dependent data. Such data arise when working with longitudinal and other study designs in which multiple observations are made on each subject. Some specific linear mixed effects models are. Random intercepts models, where all responses in a ... c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of β Feb 10, 2022 · An extension of the mixed-effects growth model that considers between-person differences in the within-subject variance and the autocorrelation. Stat Med. 2022 Feb 10;41 (3):471-482. doi: 10.1002/sim.9280. What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals..